I have a recipe (from the cake mix doctor) that calls for 1 cup of whole milk. I only have 2% and really don't feel like going back to the store. ha. Will it make a huge difference in how my cake turns out? If I have to run to the store...I will. haha
you can use a little cream or sour cream as well.
You could always borrow a cup of whole milk from a neighbor 
I can't say if it will affect the specific recipe or not. I just wanted to share that growing up in family of 6 kids in the days of a single working parent, my mom never had the extra money to buy what we considered the expensive stuff .... we used margarine, not butter; it was always 2% milk, not whole milk; salad dressing instead of mayonnaise.
I get a good chuckle during commercials and cooking shows that indicate "....only the finest ingredients, just like your mom used!" 
Maybe I grew up on the really poor side of the tracks, but none of the moms I knew ever went to the gourmet shops and bought high priced imported chocolate, expensive cream and real butter. They went to the local grocery and bought Nestle's choc chips, cheap milk and store brand margarine.
And made the best chocolate chip cookies we ever tasted! 
I just heard on one of the shows on Food network that the water (i think) separates from the milk when using part skim which is why the recipe may not come out right.. i've always used 2% whenever a recipe called for milk which isn't too often, but i've never had a problem.
I bake from scratch and there's ALWAYS 2% or 1% milk in the 'fridge! I didn't even give it a second thought until recently LOL! I bet it'll be fine
I can't say if it will affect the specific recipe or not. I just wanted to share that growing up in family of 6 kids in the days of a single working parent, my mom never had the extra money to buy what we considered the expensive stuff .... we used margarine, not butter; it was always 2% milk, not whole milk; salad dressing instead of mayonnaise.
I get a good chuckle during commercials and cooking shows that indicate "....only the finest ingredients, just like your mom used!"
Maybe I grew up on the really poor side of the tracks, but none of the moms I knew ever went to the gourmet shops and bought high priced imported chocolate, expensive cream and real butter. They went to the local grocery and bought Nestle's choc chips, cheap milk and store brand margarine.And made the best chocolate chip cookies we ever tasted!
LOL I know what you mean! It wasn't MY mom either! 
I'm with mom2spunkynbug, i bake from scratch and always use 1%.
I'm glad to know there wouldn't be a big difference!!! However, I called my mom and, because she's the BEST, she brought me over some whole milk. haha. I know...I'm spoiled. 
Thank you SOOOO much for all your help!!
I usually use 2%, not a noticeable difference, if at all. And if you look at the fat content, it's really not that big of a difference either (although those of us that drink it like to think it is).
BTW you can also use, cup for cup, either buttermilk, sourcream, or yogurt for subs.
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