It will be a 4-tiered cake, 6" 8" 10" and 12" delivered 45 minutes away (of course, during the hottest weekend in summer)

I'm thinking I'll need to take it with the top two tiers together and bottom two tiers together. Assemble the 2 on site.

I can't see assembling the whole thing on site as the ribbon needs to look somewhat seamless.

By the way, the "OMG" was written by the bride. she found this out of a magazine.

I'd do the bottom three at home and travel with them then put the top tier on onsite. The stacked 8/10/12 is manageable to lift.

Without a doubt use SPS.

I would never think of putting stacked cakes in my car. Because of where I live, I never have very far to drive.
I did however, find this video. I have put one spike down the middle of the cake but never two.
I think this may help you out. Good Luck!

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From what I gather, Edna's kind of a rock star in the cake decorating world!